Abstract
COMPOUNDS which effect cell division are interesting because they have the potential of increasing our knowledge about this poorly understood biological process. The cytochalasin compounds fall into this category because they can influence both cellular and nuclear division. Cytochalashis are metabolites derived from moulds, and have recently been isolated by Dr W. B. Turner and their molecular structure reported by Aldridge et al.1. Carter has shown some of the effects of the cytochalasin B on Earle's L strain of mouse fibroblasts in culture2. In varying conditions of concentration and time, the compound inhibited cell motility, produced extrusion of the nucleus and blocked cytoplasmic cleavage, nuclear division continuing with the production of multinucleated cells.
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References
Aldridge, D. C., Armstrong, J. J., Speake, R. N., and Turner, W. B., Chem. Commun., 1, 26 (1967).
Carter, S. B., Nature, 213, 261 (1967).
Moorhead, P. S., Nowell, P. C., Mellman, W. J., Battips, D. M., and Hunger-ford, D. A., Exp. Cell Res., 20, 613 (1960).
Rothfels, K. H., and Siminovitch, L., Stain Tech., 33, 73 (1958).
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SMITH, G., RIDLER, M. & FAUNCH, J. Action of Cytochalasin B on Cultured Human Lymphocytes. Nature 216, 1134–1135 (1967). https://doi.org/10.1038/2161134a0
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DOI: https://doi.org/10.1038/2161134a0
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