Haemostatic Plugs in Experimental Scurvy

Abstract

Born and Paylirig Wright1 found that the blood platelets of weanling guinea-pigs fed on a scorbutogenic diet show decreased adhesiveness. These results suggested to them that the haemorrhages of scurvy might be caused either by the failure of the platelets to adhere to form effective haemostatic plugs, or because of some unexplained mechanism, to maintain normal capillary resistance. We have repeated these experiments and, in addition to measuring the adhesiveness of platelets to glass, we have studied the formation of haemostatic plugs by direct observation.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Bora, G. V. R., and Payling Wright, H., Lancet, i, 477 (1967).

    Google Scholar 

  2. 2

    Kellie, A. E., and Zilva, S. S., Biochem. J., 35, 783 (1941).

    CAS  Article  Google Scholar 

  3. 3

    Honour, A. J., and Ross Russell, R. W., Brit. J. Exp. Path., 43, 350 (1961).

    Google Scholar 

  4. 4

    Emmons, P. R., Harrison, M. J. G., Honour, A. J., and Mitchell, J. R. A., Lancet, ii, 603 (1965).

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

HARRISON, M., HONOUR, A. Haemostatic Plugs in Experimental Scurvy. Nature 216, 1119–1120 (1967). https://doi.org/10.1038/2161119a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.