Abstract
Born and Paylirig Wright1 found that the blood platelets of weanling guinea-pigs fed on a scorbutogenic diet show decreased adhesiveness. These results suggested to them that the haemorrhages of scurvy might be caused either by the failure of the platelets to adhere to form effective haemostatic plugs, or because of some unexplained mechanism, to maintain normal capillary resistance. We have repeated these experiments and, in addition to measuring the adhesiveness of platelets to glass, we have studied the formation of haemostatic plugs by direct observation.
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References
Bora, G. V. R., and Payling Wright, H., Lancet, i, 477 (1967).
Kellie, A. E., and Zilva, S. S., Biochem. J., 35, 783 (1941).
Honour, A. J., and Ross Russell, R. W., Brit. J. Exp. Path., 43, 350 (1961).
Emmons, P. R., Harrison, M. J. G., Honour, A. J., and Mitchell, J. R. A., Lancet, ii, 603 (1965).
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HARRISON, M., HONOUR, A. Haemostatic Plugs in Experimental Scurvy. Nature 216, 1119–1120 (1967). https://doi.org/10.1038/2161119a0
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DOI: https://doi.org/10.1038/2161119a0
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