Maternofoetal Transfer of γ G Immunoglobulins


BRAMBELL has suggested that the mechanisms which underlie the transmission of antibodies and other plasma proteins from mother to foetus are similar to those which operate in the catabolism of these proteins1. This concept was supported by the observation that maternofoetal transfer of homologous and heterologous γG globulins in the rabbit decreased with the half lives of these proteins1; the species order of decreasing maternofoetal transmission2 arid decreasing half life3 in the rabbit was rabbit > man > ginea-pig > horse > bovine. In this study, the maternofoetal transfer of γG globulin was examined in the mouse, rat and guinea-pig.

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KOCH, C., BOESMAN, M. & GITLIN, D. Maternofoetal Transfer of γ G Immunoglobulins. Nature 216, 1116–1117 (1967).

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