Metabolism of 3H-Myoglobin


PERKOFF1 has recently emphasized the paucity of information on myoglobin metabolism and the importance of this haemoprotein in the myoglobinurias. Previous attempts to study the turnover of myoglobin by administering 14C-glycine-2 to rats met with limited success because of the poor incorporation of isotope and non-specific labelling of the molecule (that is, haem and globin). We now describe a new technique for preparing 3H-myoglobin labelled with haem and studies of its turnover and degradation are reported.

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DALY, J., LITTLE, J., TROXLER, R. et al. Metabolism of 3H-Myoglobin. Nature 216, 1030–1031 (1967).

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