Factors influencing Lysis of Whole Blood Clots

  • A Corrigendum to this article was published on 30 December 1967


LITTLE is known about the mechanism by which blood clots or fibrin monolayers usually lyse. The enzyme plasmin (fibrinolysin) has been assumed to play a key part in this mechanism and for this reason plasmin, its substrates fibrinogen and fibrin and its naturally occurring inhibitors have all been extensively studied and characterized1. The biological importance of these studies has depended on the assumption that the plasmin system serves to maintain the homeostatic balance between the polymerization of fibrin and the dissolution of this polymer. Although much is known about the activation of the polymerization phase of this homeostatic system, there is little information about the mode of activation of the clot dissolving or plasmin system in the intact blood clot. We describe here in qualitative terms some of the factors and steps involved in the lysis of a clot from whole blood diluted 1: 10 with phosphate buffer2.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Cohen, S. I., and Warren, R., New Engl. J. Med., 264, 79 (1961).

  2. 2

    Fearnley, G. R., Bandforth, G., and Fearnley, E., Clin. Sci., 16, 645 (1957).

  3. 3

    Taylor, F. B., and Staprans, I., Arch. Biochem. and Biophy., 114, 38 (1966).

  4. 4

    Müller-Eberhard, H. J., Dalmasso, A. G., and Calcott, M. A., J. Exp. Med., 123, 33 (1966).

  5. 5

    Müller-Eberhard, H. J., and Biro, C. E., J. Exp. Med., 118, 447 (1963).

  6. 6

    Kabat, E. A., and Mayer, M. M., Experimental Immunochemistry, 762 (Charles C. Thomas, Springfield, Illinois, 1961).

  7. 7

    Müller-Eberhard, H. J., Fed. Proc., 26, 744 (1967).

  8. 8

    Linscott, W. D., and Nishioka, K., J. Exp. Med., 118, 795 (1963).

  9. 9

    James, N. T., Johnson, S. A., Monto, R. W., Diab, G., and Caldwell, J., Blood, 19 (1962).

  10. 10

    Harboe, M., Müller-Eberhard, H. J., Fudenberg, H., Polley, M. J., and Mallison, P. L., Immunology, 6, 412 (1963).

  11. 11

    Cooper, N. R., and Becker, E. L., J. Immunol., 98, 119 (1967).

Download references

Author information



Additional information

An erratum to this article is available at https://doi.org/10.1038/2161358e0

Rights and permissions

Reprints and Permissions

About this article

Cite this article

TAYLOR, F., MÜLLER-EBERHARD, H. Factors influencing Lysis of Whole Blood Clots. Nature 216, 1023–1025 (1967). https://doi.org/10.1038/2161023a0

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.