Abstract
INHIBITION of respiration by azide has been known for many years. It is now generally considered that azide not only inhibits electron transfer through the cytochrome chain, presumably by inhibiting cytochrome oxidase1,2, but that it also inhibits one of the associated reactions involved in the production of ATP (refs. 3 and 4), The reactions of phosphorylation seem to be more sensitive to azide than the electron transfer reactions because smaller concentrations of azide are required to inhibit oxygen uptake in the presence of ADP and inorganic phosphate than in their absence5,6, that is, state 3 respiration is more sensitive to azide than state 4 respiration.
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HODGES, T., ELZAM, O. Effect of Azide and Oligomycin on the Transport of Calcium Ions in Corn Mitochondria. Nature 215, 970–972 (1967). https://doi.org/10.1038/215970a0
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DOI: https://doi.org/10.1038/215970a0
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