Abstract
INCREASED vascular permeability is an important feature of thermal injury, as it is of all inflammatory processes. The phenomenon is often biphasic: the early transient response is mediated by a substance inhibited by antihistamine drugs, while the more intense and prolonged delayed response is mediated by factors which are not influenced by antihistamines. A permeability factor isolated by us from lesions during the delayed response to thermal injury was found to be distinct from previously described permeability factors which are either proteases (PF/dil, kallikrein), proteins (lymph node permeability factor), or peptides (leukotaxin, bradykinin, kallidin)1–4. This communication deals with further purification of the burns permeability factor.
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HAYASHI, H., TASAKI, I. & YOSHINAGA, M. Permeability Factors of Rabbit Skin associated with Delayed Vascular Response to Thermal Injury. Nature 215, 759–760 (1967). https://doi.org/10.1038/215759a0
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DOI: https://doi.org/10.1038/215759a0
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