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Induction of Mitotic Recombination in Saccharomyces cerevisiae by Ethyl Methane Sulphonate


MITOTIC recombination can be induced in Saccharomyces cerevisiae by exposing them to ultra-violet and X-radiation1. The genetic maps so obtained closely parallel those from meiotic recombination2. One of the most useful features of mitotic recombination is that it is relatively easy to observe intracistronic recombination. It is possible that this results from a mechanism somewhat different from that leading to meiotic recombination characteristic of higher organisms. For this reason, we decided to study the effects of certain chemical mutagens on the process of mitotic recombination in the hope of being able ultimately to compare these results with those obtained in more usual systems.

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  1. Manney, T. R., and Mortimer, R. K., Science, 143, 581 (1964).

    Article  ADS  CAS  Google Scholar 

  2. Esposito, M. S., Genetics, 54, 334 (1966).

    Google Scholar 

  3. Lawley, P. D., and Brooks, P., Biochem. J., 89, 127 (1963).

    Article  CAS  Google Scholar 

  4. Neuffer, M. G., and Ficsor, G., Science, 139, 1296 (1963).

    Article  ADS  CAS  Google Scholar 

  5. Morpurgo, G., Genetics, 48, 1259 (1963).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Zimmerman, F. K., Schwaier, R., and v. Laer, U., Z. Vererbungsl., 98, 230 (1966).

    Google Scholar 

  7. Fink, G. R., Genetics, 53, 445 (1966).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Roman, H. K., and Jacob, F., C.R. Acad. Sci., Paris, 245, 1032 (1957).

    CAS  Google Scholar 

  9. Holliday, R., Genet. Res., 5, 282 (1964).

    Article  Google Scholar 

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YOST, H., CHALEFF, R. & FINERTY, J. Induction of Mitotic Recombination in Saccharomyces cerevisiae by Ethyl Methane Sulphonate. Nature 215, 660–661 (1967).

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