The Nucleolus and Trisomy

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EVANS1 has argued that in the human oocyte attachment of acrocentric chromosomes to a persistent nucleolus during the first metaphase of meiosis may be an important cause of non-disjunction involving these chromosomes. The critical stages of meiosis in oocytes are difficult to examine, but Evans's hypothesis may receive indirect support from examples of the mechanism in mitosis. We have recently observed what appears to be such an example.

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  1. 1

    Evans, H. J., Nature, 214, 361 (1967).

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