Abstract
THE work of Heller and Stulc1 has been followed by several reports of methods designed to increase the sensitivity of the rat for the assay of vasopressin. In many of these reports the greater sensitivity has been attributed to a more careful operative technique, which may reduce the basal level of endogenous vasopressin secretion by the rat2,3. Czaczkes et al.2, confirming the earlier work1, suggested using pre-operated rats in order to avoid surgical trauma on the day of assay, but Jones and Lee4 did not find the pre-operated rat to be any more sensitive. It seemed desirable therefore to establish whether a high basal level of vasopressin would, in fact, decrease the response of the rat preparation to vasopressin injections.
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References
Heller, J., and Stulc, J., Physiol. Bohemoslov., 8, 558 (1959).
Czaczkes, J. W., Kleeman, C. R., and Koenig, M., J. Clin. Invest., 43, 1625 (1964).
Tata, P. S., and Buzalkov, R., PflügerS Arch. ges. Physiol., 290, 294 (1966).
Jones, J. J., and Lee, J., J. Endocrinol., 33, 329 (1965).
Jones, J. J., and Lee, J., J. Endocrinol., 37, 335 (1967).
Tata, P. S., and Gauer, O. H., Pflügers Arch. Ges. Physiol., 290, 279 (1966).
Bisset, G. W., in Mem. Soc. Endocrinol. (edit. by Pickles and Fitzpatrick), 14, 198 (Cambridge University Press, 1966).
Csapo, A., in Oxytocin (edit. by Caldeyro-Barcia and Heller), 100 (Pergamon Press, 1961).
Harvey, N., Jones, J. J., and Lee, J., J. Endocrinol., 38, 163 (1967).
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FORSLING, M., JONES, J. & LEE, J. Intravenous Infusion of Vasopressin to increase the Sensitivity of its Assay in the Water–Ethanol Loaded Rat. Nature 215, 433–434 (1967). https://doi.org/10.1038/215433a0
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DOI: https://doi.org/10.1038/215433a0
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