Abstract
THERE have been several reports indicating a possible interrelationship between plasma lipoprotein lipase activity and blood platelets. Mitchell1 and Gardikas et al.2, using changes in the optical density of plasma as indicators of lipolytic activity, have reported an inhibition of lipoprotein lipase activity by platelets. The presence of platelets contributes materially to plasma turbidity, however, and the changes in optical density, particularly proportionate changes, may not be an accurate measure of lipase activity. Hollett and Nestel3 have shown that the clearing activity after administration of heparin, as measured by changes in optical density, and lipolytic activity, as determined by glycerol production, do not necessarily parallel each other. More recent results indicate that the lipoprotein lipase activity and “stickiness” of blood platelets are both altered in human cardiovascular disease4. We therefore decided to reinvestigate the relationship between lipoprotein lipase and blood platelets using heparin as an inducer and the release of free fatty acids (FFA) as a measure of the lipolytic activity.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Mitchell, J. R. A., Lancet, i, 169 (1959).
Gardikas, C., Thomopoulos, D., Arapakis, G., and Nassi, H., Acta Haematol., 24, 274 (1960).
Hollett, C., and Nestel, P. J., Amer. J. Physiol., 199, 803 (1960).
Slack, J., Seymour, J., McDonald, L., and Love, F., Lancet, ii, 1033 (1964).
Dole, V. P., and Meinertz, H., J. Biol. Chem., 235, 2595 (1960).
Smith, J. C., and Barboriak, J. J., Amer. J. Physiol. (in the press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BARBORIAK, J. Post-heparin Lipolytic Activity and Blood Platelets. Nature 215, 163–164 (1967). https://doi.org/10.1038/215163a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/215163a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.