Abstract
THE lysosomal fraction of the leucocyte is the principal source of peroxidase and hydrolases1, and our unpublished results show that it also contains lactic dehydrogenase (LDH) usually found in the soluble compartment of cells. Vesell and Bearn2 and Vesell and Osterland et al.3 have shown that whole homogenates and sonicates of the leucocyte contain four isozymes of lactic dehydrogenase. In this communication we shall show that the isozymes of lactic dehydrogenase of the human white cell are bound to the particulate of the lysosomal fraction, and that this accounts for all the isozymes of the white cell.
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References
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JOHN, S., BERGER, N., BONNER, M. et al. Localization of Lactic Dehydrogenase Isozymes in Lysosomal Fraction of the Neutrophil of Normal Human Blood. Nature 215, 1483–1485 (1967). https://doi.org/10.1038/2151483b0
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DOI: https://doi.org/10.1038/2151483b0
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