Abstract
SV40 virus is of considerable concern, because it has been shown to be present in a number of samples of inactivated polio virus and adenovirus vaccines produced before 1960, and it is capable of inducing both chromosomal changes and tumours in certain experimental systems. Since the isolation of SV40 virus from naturally infected monkeys was reported by Sweet and Hilleman1, several investigators have examined experimental infection in monkeys and man with this agent. It has been shown that infection can be produced in African green monkeys by several routes of inoculation2,3. Inoculation of human volunteers4–7 has resulted in low grade infection including some evidence of transient chromosomal changes. Furthermore, administration of this virus to hamsters has resulted in the production of tumours6,8.
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References
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FABIYI, A., CALCAGNO, P., SEVER, J. et al. Isolation of SV40 Virus and its Effect on Renal Function in African Green Monkeys. Nature 215, 88–89 (1967). https://doi.org/10.1038/215088a0
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DOI: https://doi.org/10.1038/215088a0
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