Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Differentiation of Receptor Systems activated by Sympathomimetic Amines

Abstract

CLASSIFICATION of receptor systems which are activated by sympathomimetic amines has engaged the attention of many investigators. Ahlquist1–3 has suggested the convenient designations of alpha (α) and beta (β) to distinguish major differences in the responses elicited in various organ systems. Our investigations have provided results which cannot be explained easily on the assumption that the β-type designates a single receptor population4–6. We now report additional studies which show that two distinct receptor types are at present included within this group.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Ahlquist, R. P., Amer. J. Physiol., 154, 586 (1948).

    Google Scholar 

  2. 2

    Ahlquist, R. P., Arch. Intern. Pharmacodyn., 139, 38 (1962).

    CAS  Google Scholar 

  3. 3

    Ahlquist, R. P., J. Pharm. Sci., 55, 359 (1966).

    CAS  Article  Google Scholar 

  4. 4

    Lands, A. M., and Brown, T. G., jun., Proc. Soc. Exp. Biol. and Med., 116, 331 (1964).

    CAS  Article  Google Scholar 

  5. 5

    Lands, A. M., Groblewski, G. E., and Brown, T. G., jun., Arch. Intern. Pharmacodyn., 161, 68 (1966).

    CAS  Google Scholar 

  6. 6

    Arnold, A., McAuliff, J. P., Luduena, F. P., Brown, T. G., jun., and Lands, A. M., Fed. Proc., 25, 500 (1966).

    Google Scholar 

  7. 7

    v. Handel, E., and Zilversmit, D. B., J. Lab. Clin. Med., 50, 152 (1957).

    Google Scholar 

  8. 8

    Černohorsky, M., Čepelik, J., Lincová, D., and Wenke, M., J. Pharm Pharmacol., 18, 188 (1966); ibid., 18, 190 (1966).

    Article  Google Scholar 

  9. 9

    Brown, T. G., jun., and Lands, A. M., in Evaluation of Drug Activities: Pharmacometrics (edit. by Lawrence, D. R., and Bacharach, A. L.), 1, 353 (Academic Press, London and New York, 1964).

    Book  Google Scholar 

  10. 10

    Luduena, F. P., Miller, E., and Wilt, W. A., J. Amer. Pharm. Assoc. (Sc. Ed.), 44, 363 (1955).

    CAS  Article  Google Scholar 

  11. 11

    Brown, T. G., jun., and Green, T. J., Amer. Heart. J., 63, 545 (1962).

    CAS  Article  Google Scholar 

  12. 12

    Pratesi, P., Grana, E., Lilla, L., LaManna, A., and Villa, L., Il Farmaco—Ed. Sc., 18, 920, (1963).

    CAS  Google Scholar 

  13. 13

    Mueller, P. S., and Horwitz, D., J. Lipid Res., 3, 251 (1962).

    CAS  Google Scholar 

  14. 14

    v. Rossum, J. M., J. Pharm. Pharmacol., 17, 202 (1965).

    Article  Google Scholar 

  15. 15

    Lands, A. M., and Brown, T. G., jun., Chemical Constitution and Pharmacodynamic Action (edit. by Burger, A.), 1 (Marcel Dekker, Inc., New York, in the press).

  16. 16

    Moran, N. C., and Perkins, M. E., J. Pharmacol. Exp. Therap., 124, 223 (1958).

    CAS  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

LANDS, A., ARNOLD, A., MCAULIFF, J. et al. Differentiation of Receptor Systems activated by Sympathomimetic Amines. Nature 214, 597–598 (1967). https://doi.org/10.1038/214597a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing