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Synergistic Toxicity and Carcinogenicity of ‘Freons’ and Piperonyl Butoxide

Naturevolume 214pages526528 (1967) | Download Citation

Subjects

  • A Corrigendum to this article was published on 08 July 1967

Abstract

‘FREONS’ are fluorocarbons, with 1–4 carbon atoms, fluorine and sometimes chlorine, bromine or hydrogen, which are widely used as propellants (for example, with pressurized aerosols of foods or pesticides), fire extinguishers, solvents, and refrigerants. ‘Freons’ have low toxicity after acute or chronic inhalation exposures1,2, with the exception of halothane, CF3-CHBrCl, which has produced occasional hepatotoxicity, possibly as a result of fluoroalkene contaminant3.

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Author information

Affiliations

  1. Laboratories of Carcinogenesis and Histology, Children's Cancer Research Foundation, Inc.

    • SAMUEL S. EPSTEIN
    • , S. JOSHI
    • , J. ANDREA
    • , P. CLAPP
    • , H. FALK
    •  & N. MANTEL
  2. Department of Pathology, Harvard Medical School, Boston, Massachusetts

    • SAMUEL S. EPSTEIN
    • , S. JOSHI
    • , J. ANDREA
    • , P. CLAPP
    • , H. FALK
    •  & N. MANTEL
  3. Carcinogenesis Studies Section, National Cancer Institute, Bethesda, Maryland

    • SAMUEL S. EPSTEIN
    • , S. JOSHI
    • , J. ANDREA
    • , P. CLAPP
    • , H. FALK
    •  & N. MANTEL

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https://doi.org/10.1038/214526a0

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