Letter | Published:

Intermediary Metabolites and Adenine Nucleotides in Leucocytes of Children with Protein–Calorie Malnutrition

Naturevolume 214pages525526 (1967) | Download Citation

Subjects

Abstract

THE possibility of impaired energy metabolism in kwashiorkor (protein–calorie malnutrition of children) has been suggested by many investigators1–4. Our previous observations of muscle demonstrated that not only were the contents of phosphoenolpyruvate and oxaloacetate markedly reduced, but also activities of the enzymes pyruvic kinase, isocitric dehydrogenase and malic dehydrogenase were decreased significantly5. These observations suggested inhibition of terminal glycolysis and citric acid cycle metabolism and, therefore, of cellular energy metabolism.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Waterlow, J. C., Proc. Roy. Soc., B., 155, 96 (1961).

  2. 2

    Cat, I., Campello, A. P., Voss, D. O., Braga, H., and Bacila, M., Lancet, ii, 415 (1963).

  3. 3

    Gillman, J., Gillman, T., Scragg, J., Savage, N., Gilbert, C., Trout, G., and Levy, P., S. African J. Med. Sci., 76, 31 (1961).

  4. 4

    Metcoff, J., Frenk, S., Antonowicz, I., Gordillo, G., and Lopez, E., Pediatrics 26, 960 (1960).

  5. 5

    Metcoff, J., Yoshida, T., Frenk, S., Torres-Pinedo, R., Kaiser, E., and Hansen, J. D. L., Medicine, 45, 365 (1966).

  6. 6

    Bazin, S., and Delaunary, A., Rev. Franç. Etudes clin. biol., 1, 1019 (1956).

  7. 7

    Martin, S. P., McKinney, G. R., and Green, R., Ann. N.Y. Acad. Sci., 59, 996 (1955).

  8. 8

    Karnovsky, M. L., Biological Activity of the Leucocyte, Ciba Foundation Study Group No. 10 (edit. by Wolstenholme, G. E. W., and O'Connor, M.), 60 (J. and A. Churchill Ltd., 1961).

  9. 9

    Frei, J., Borel, C., Horvath, G., Gullity, B., and Vannotti, A., Blood, 18, 317 (1961).

  10. 10

    Burch, H. B., Arroyave, G., Schwartz, R., Padilla, A. M., Behar, M., Viteri, F., and Scrimshaw, N. S., J. Clin. Invest., 36, 1579 (1957).

  11. 11

    Christlieb, A. R., Sbarra, A. J., and Bardawil, W. A., J. Clin. Pathol., 37, 257 (1962).

  12. 12

    Czok, R., and Eckert, L., Methods of Enzymatic Analysis (edit. by Bergmeyer, H. U.), 229 (Verlag Chimie/Academic Press, 1963).

  13. 13

    Hohorst, H-J., in Methods of Enzymatic Analysis (edit. by Bergmeyer, H.U.), 266 (Verlag Chimie/Academic Press, 1963).

  14. 14

    Bergmeyer, H. U., and Bernt, E., in Methods of Enzymatic Analysis (edit. by Bergmeyer, H. U.), 324 (Verlag Chimie/Academic Press, 1963).

  15. 15

    Adam, H., in Methods of Enzymatic Analysis (edit. by Bergmeyer, H. U.), 539 (Verlag Chimie/Academic Press, 1963).

  16. 16

    Eggelston, L. V., and Hems, R., Biochem. J., 52, 156 (1952).

  17. 17

    Atkinson, M. R., Burton, R. M., and Morton, R. K., Biochem. J., 78, 813 (1961).

  18. 18

    Lowry, O. H., Passoneau, J. V., Hasselberger, F. V., and Schulz, D. W., J. Biol. Chem., 239, 18 (1963).

  19. 19

    Krebs, H. A., and Eggelston, L. V., Biochem. J., 94, 3C (1965).

  20. 20

    Lardy, H. A., Foster, D. O., Shrago, E., and Ray, P. D., Adv. Enzyme Reg., 2 (edit. by Weber, G.), 39 (1964).

  21. 21

    Weber, G., Singhal, R. L., and Srivastava, S. K., Adv. Enzyme Reg., 3 (edit. by Weber, G.), 43 (1965).

Download references

Author information

Affiliations

  1. Departments of Pediatrics, Michael Reese Hospital and Medical Center, Chicago. The Chicago Medical School, Chicago

    • TAKASHI YOSHIDA
    •  & JACK METCOFF
  2. Hospital de Pediatria, Centro Medico, IMSS, Mexico

    • SILVESTRE FRENK
    •  & CARMEN DE LA PENA

Authors

  1. Search for TAKASHI YOSHIDA in:

  2. Search for JACK METCOFF in:

  3. Search for SILVESTRE FRENK in:

  4. Search for CARMEN DE LA PENA in:

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/214525a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.