Abstract
SILICA in the particulate form has been shown to have a lytic action on intracellular structures1–3 and on erythrocytes3,4. The present investigation has shown that chrysotile asbestos is as potent a haemolytic agent as silica powder. Other forms of asbestos lysed erythrocytes only after prolonged incubation with them, and a wide range of mineral dusts was inactive. The haemolytic action of chrysotile was completely prevented by disodium versenate and simple phosphates but only partially by polyvinylpyridine-N-oxide and aluminium, both of which protect cells against lysis by silica1.
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MACNAB, G., HARINGTON, J. Haemolytic Activity of Asbestos and other Mineral Dusts. Nature 214, 522–523 (1967). https://doi.org/10.1038/214522a0
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DOI: https://doi.org/10.1038/214522a0
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