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Activity of a Macrophage Factor in Collagen Formation by Silica


THE first response of cells to the deposition of free silica particles is phagocytosis. The way in which this is followed by fibrosis is not understood, although macrophages are thought to liberate a fibrogenic agent when they die1–4. There is a correlation between the toxicity of various forms of silica and of other particulate materials to macrophages in culture and the capacity of these particles to stimulate fibrosis in vivo2,5–7, but this relationship does not seem to have been demonstrated directly in tissue culture.

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HEPPLESTON, A., STYLES, J. Activity of a Macrophage Factor in Collagen Formation by Silica. Nature 214, 521–522 (1967).

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