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Petite Mutants induced in Yeast by Dithranol (1,8,9-trihydroxyanthracene), an Important Therapeutic Agent against Psoriasis

Naturevolume 214page415 (1967) | Download Citation



DITHRANOL (1,8,9-trihydroxyanthracene) is one of the most important local therapeutic agents against the common skin disease, psoriasis. The mechanism of the effect of this compound is not completely known. In recent experiments, however, it has been shown that dithranol forms a complex with nucleic acids, and it was proposed that dithranol thereby acts as a cytostatic agent1. To verify this hypothesis the effect of dithranol on the thymidine incorporation of guinea-pig epidermis was investigated. It was shown that twelve hours application of dithranol in the form of an ointment decreases the number of labelled cells to a third of that of the untreated epidermis2.

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  1. 1

    Swanbeck, G., and Thyresson, N., Acta Dermato-Venerol., 45, 344 (1965).

  2. 2

    Swanbeck, G., and Lidén, S., Acta Dermato-Venerol., 46, 228 (1966).

  3. 3

    Nagai, S., Yangishima, N., and Nagai, H., Bacteriol. Rev., 25, 404 (1961).

  4. 4

    Schoental, R., in Polycyclic Hydrocarbons (edit. by Clar, E.), 1, 133 (Academic Press, London, 1964).

  5. 5

    Bock, F. G., and Burns, R., J. Nat. Cancer Inst., 30, 393 (1963).

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  1. Institute of Genetics, University of Uppsala

    • B. O. GILLBERG
  2. Institute of Physiological Botany, University of Uppsala

  3. Department of Dermatology, University Hospital, Uppsala



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