Letter | Published:

Differentiation of Synaptic Bulbs in Clarke's Column

Naturevolume 214pages391392 (1967) | Download Citation

Subjects

Abstract

INVESTIGATIONS of the fine structure of synaptic junctions have revealed a morphological differentiation of apposed synaptic membranes and associated presynaptic and postsynaptic elements1–4. Presynaptic terminals have been shown to contain agranular synaptic vesicles, although larger granular vesicles have also been reported5,6. Two kinds of axonal terminals were recently identified, one of which contains spherical, and the other flattened, agranular vesicles. The observation was made in boutons synapsing with dendrites in the molecular layer of the cerebellum7 and in boutons synapsing with anterior horn cells of the spinal cord8. This communication reports observations on two forms of synaptic vesicles which can be used to differentiate two types of boutons found within Clarke's column of the monkey (Saimiri sciureus). This nucleus of the dorsal column is found in the spinal cord at thoracic and upper lumbar levels. It receives proprioceptive impulses chiefly from neuromuscular spindles and Golgi tendon organs. These impulses are relayed to the cerebellum by spinocerebellar tracts.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Palay, S. L., and Palade, G. E., J. Biophys. Biochem. Cytol., 1, 69 (1955).

  2. 2

    DeRobertis, E. D. P., Exp. Cell Res., Suppl. 5, 347 (1958).

  3. 3

    Gray, E. G., J. Anat., 93, 420 (1959).

  4. 4

    Gray, E. G., J. Anat., 95, 345 (1961).

  5. 5

    Sedar, A. W., and Moskowitz, N., Anat. Rec., 148, 334 (1964).

  6. 6

    Nathaniel, E. J. H., and Nathaniel, D. R., J. Ultrastruct. Res., 14, 540 (1966).

  7. 7

    Uchizono, K., Nature, 207, 642 (1965).

  8. 8

    Bodian, D., Science, 151, 1093 (1966).

  9. 9

    Karlsson, U., and Schultz, R. L., J. Ultrastruct. Res., 12, 160 (1965).

  10. 10

    Bodian, D., Anat. Rec., 154, 319 (1966).

  11. 11

    Laporte, Y., Lundberg, A., and Oscarsson, O., Acta Physiol. Scand., 36, 188 (1956).

Download references

Author information

Affiliations

  1. Daniel Baugh Institute of Anatomy, Jefferson Medical College, Philadelphia, Pennsylvania

    • ALBERT W. SEDAR
    •  & NORMAN MOSKOWITZ

Authors

  1. Search for ALBERT W. SEDAR in:

  2. Search for NORMAN MOSKOWITZ in:

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/214391a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.