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The Nucleolus, Virus Infection, and Trisomy in Man

Naturevolume 214pages361363 (1967) | Download Citation

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Abstract

The virus of infectious hepatitis has been suggested on epidemiological grounds as a causative factor in Down's syndrome (mongolism). If this hypothesis is correct, the virus may produce its effects not by inducing chromosome breaks but by an effect on the nucleolus of the ovum leading to a failure of separation of half-bivalents during meiosis. The persistence of the nucleolus during meiosis may also be the mechanism by which other forms of trisomy are produced.

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Affiliations

  1. Department of Genetics, University of Aberdeen, Marischal College

    • H. J. EVANS

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https://doi.org/10.1038/214361a0

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