Letter | Published:

Activity of Phenethanolamine N-Methyl Transferase in the Adrenal Glands of Foetal and Neonatal Rats

Naturevolume 214page190 (1967) | Download Citation



THE proportions of adrenaline and noradrenaline in the adrenal glands differ from one species to another and within a species during development. Comline and Silver1 have compiled a list of reports showing the percentage of noradrenaline in the adrenal gland catecholamines of foetal, newly born and adult animals of seven species. In general, a higher proportion of noradrenaline is associated with the foetal state and a higher proportion of adrenaline with the adult animal, which suggests that the ability of the adrenal glands to form adrenaline develops late in the foetal life or in the early life of the animal.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Comline, R. S., and Silver, M., Brit. Med. Bull., 22, 16 (1966).

  2. 2

    Kirshner, N., Pharmacol. Rev., 11, 350 (1959).

  3. 3

    Kirshner, N., and Goodall, McC., Biochim. Biophys. Acta, 24, 658 (1957).

  4. 4

    Axelrod, J., J. Biol. Chem., 237, 1657 (1962).

  5. 5

    Fuller, R. W., and Hunt, J. M., Anal. Biochem., 16, 349 (1966).

  6. 6

    Josimovich, J. B., Ladman, A. J., and Deane, H. W., Endocrinology, 54, 627 (1954).

  7. 7

    Kamoun, A., Mialhe, Voloss, C., and Stutinsky, F., C.R. Acad. Sci., Paris, 259, 3079 (1964).

  8. 8

    Cheoux, G., and Roffi, J., C.R. Acad. Sci., Paris, 260, 6702 (1965).

Download references

Author information


  1. Division of Biology and Pharmacology, The Lilly Research Laboratories, Eli Lilly and Co., Indianapolis, 6, Indiana

    •  & JOSEPH M. HUNT


  1. Search for RAY W. FULLER in:

  2. Search for JOSEPH M. HUNT in:

About this article

Publication history

Issue Date



Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.