Article | Published:

Mode of Anticholinergic Action of Local Anaesthetics

Naturevolume 214pages151153 (1967) | Download Citation

Subjects

Abstract

An examination of the theory of Nachmansohn, that acetylcholine regulates the permeability cycle in excitable cells, has led to the finding that blockade of impulse conduction by local anaesthetics cannot be accepted as proof that a cholinergic mechanism is in operation. Local anaesthetics do not react with the active site of acetylcholine receptors but rather act directly on the movements of ions in cells.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Nachmansohn, D., Chemical and Molecular Basis of Nerve Activity (Academic Press, New York, 1959).

  2. 2

    Nachmansohn, D., Israel J. Med. Sci., 1, 1201 (1965).

  3. 3

    Higman, H. B., and Bartels, E., Biochim. Biophys. Acta, 54, 543 (1962).

  4. 4

    Dettbarn, W. D., Nature, 186, 891 (1960).

  5. 5

    Rosenberg, P., and Ehrenpreis, S., Biochem. Pharmacol., 8, 192 (1961).

  6. 6

    Davis, F. A., and Dettbarn, W. D., Biochim. Biophys. Acta, 63, 349 (1962).

  7. 7

    Rosenberg, P., and Podleski, T. R., J. Pharmacol., 137, 249 (1962).

  8. 8

    Dettbarn, W. D., and Davis, F. A., Biochim. Biophys. Acta, 66, 397 (1963).

  9. 9

    Fink, L. D., and Cervoni, P., J. Pharmacol., 109, 372 (1953).

  10. 10

    Novotny, I., Vyskocil, F., Vyklicky, L., and Beronek, R., J. Physiol. Bohemoslov., 11, 277 (1962).

  11. 11

    Ehrenpreis, S., Nature, 201, 887 (1964).

  12. 12

    Mirkin, B., and Cervoni, P., J. Pharmacol., 138, 301 (1962).

  13. 13

    Reas, H. W., and Tsai, T. H., J. Pharmacol., 152, 186 (1966).

  14. 14

    Luduena, F. P., and Branin, M. J., J. Pharm. Sci. (in the press).

  15. 15

    Bartels, E., Biochim. Biophys. Acta, 109, 194 (1965).

  16. 16

    Bartels, E., and Nachmansohn, D., Biochem. Z., 342, 359 (1965).

  17. 17

    van Rossum, J. M., and Ariens, E. J., Arch. Intern. Pharmacodyn., 136, 385 (1962).

  18. 18

    Furchgott, R. F., Ann. Rev. Pharmacol., 4, 21 (1964).

  19. 19

    Furchgott, R. F., J. Pharmacol., 111, 265 (1954).

  20. 20

    Furchgott, R. F., in Adv. in Drug Res., 3 (Academic Press, New York, in the press).

  21. 21

    Furchgott, R. F., and Burstyn, P., Ann. N.Y. Acad. Sci. (in the press).

  22. 22

    Paton, W. D. M., and Rang, H. P., Proc. Roy. Soc., B, 163, 1 (1965).

  23. 23

    Robertson, P. A., Nature, 186, 316 (1960).

  24. 24

    Durbin, R. P., and Jenkinson, D. H., J. Physiol., 157, 74 (1961).

  25. 25

    Banerjee, A. K., and Lewis, J. J., J. Pharm. Pharmacol., 15, 409 (1963).

  26. 26

    Banerjee, A. K., and Lewis, J. J., J. Pharm. Pharmacol., 16, 440 (1964).

  27. 27

    Feinstein, M. B., J. Pharmacol., 152, 516 (1966).

  28. 28

    Novotny, I., and Vyskocil, F., J. Cell. Comp. Physiol., 67, 159 (1966).

Download references

Author information

Affiliations

  1. Department of Pharmacology, State University of New York, Downstate Medical Center, Brooklyn, New York

    • MAURICE B. FEINSTEIN
    •  & MARVE PAIMRE

Authors

  1. Search for MAURICE B. FEINSTEIN in:

  2. Search for MARVE PAIMRE in:

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/214151a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.