Abstract
An examination of the theory of Nachmansohn, that acetylcholine regulates the permeability cycle in excitable cells, has led to the finding that blockade of impulse conduction by local anaesthetics cannot be accepted as proof that a cholinergic mechanism is in operation. Local anaesthetics do not react with the active site of acetylcholine receptors but rather act directly on the movements of ions in cells.
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FEINSTEIN, M., PAIMRE, M. Mode of Anticholinergic Action of Local Anaesthetics. Nature 214, 151–153 (1967). https://doi.org/10.1038/214151a0
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DOI: https://doi.org/10.1038/214151a0
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