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ATP, Activation, and the Heat of Shortening of Muscle

Naturevolume 214pages148151 (1967) | Download Citation

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  • An Erratum to this article was published on 11 November 1967

Abstract

Prof. A. V. Hill has challenged biochemists to find whether the heat of shortening of muscle has any equivalent in the chemistry of muscle. It is shown that the heat of shortening, which is reabsorbed as tension disappears, is not degraded free energy from the splitting of ATP. It must be reversibly transformed entropy from a repeated cyclic reaction such as coil-helix transitions in part of the myosin–actin cross bridges.

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Affiliations

  1. Laboratories of Biochemistry, Department of Animal Biology, School of Veterinary Medicine, and Graduate Group on Molecular Biology, University of Pennsylvania, Philadelphia, Pennsylvania

    • R. E. DAVIES
    • , M. J. KUSHMERICK
    •  & R. E. LARSON

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https://doi.org/10.1038/214148a0

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