Abstract
The brains of the foetuses of a variety of mammals contain two main electrophoretic variants of type A esterases. These are partly or completely replaced by new adult-type esterases at about the same relative stage of development in man, rat, rabbit and guinea-pig. The alterations in esterase patterns can provide a good indication of the stage of development reached by an immature animal.
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References
Myers, D. E., in The Enzymes (edit. by Boyer, P. D., Lardy, H., and Myrbäck, K.,) 4, 475 (Academic Press, New York, 1960).
Hunter, R. L., and Markert, C. L., Science, 125, 1294 (1957). Markert, C. L., and Hunter, R. L., J. Histochem. Cytochem., 7, 42 (1959).
Ecobichon, D. J., and Kalow, W., Canad. J. Biochem. Physiol., 41, 753 (1962); ibid., 42, 277 (1964).
Eränko, O., Kokko, A., and Söderholm, U., Nature, 193, 778 (1962); ibid., Ann. Med. Exp. Biol. Fenn., 40, 146 (1962).
Barron, K., Bernsohn, J., and Hess, A., J. Histochem. Cytochem., 9, 656 (1961).
Lagnado, J. R., Acta. Neurol. Scand., 38, 63 (1962).
Lagnado, J. R., and Hardy, M., in Variation in Chemical Composition of the Nervous System (edit. by Ansell, G. B.), 63 (Pergamon Press, Oxford, 1966).
Aldridge, W. N., Biochem. J., 53, 110 (1953). Aldridge, W. N., Ann. Rep. Prog. Chem., 53, 294 (1956).
Augustinsson, K.-B., Ann. N. Y. Acad. Sci., 94, 844 (1961).
Bernsohn, J., Barron, K., Hess, A., and Hedrick, M., J. Neurochem., 10, 783 (1963).
Smithies, O., Adv. Protein Chem., 14, 65 (1960).
Gratzer, W. B., and Beavan, G. H., Clin. Chim. Acta, 5, 577 (1960).
Huggett, A., and Widdas, W., J. Physiol., 114, 306 (1951).
Bernsohn, J., Barron, K., and Norgello, H., Biochem. J., 91, 24c (1964).
Whittaker, V., Biochem. J., 72, 694 (1959).
McIlwain, H., Biochemistry and the Central Nervous System (J. and A. Churchill, London, 1966).
Flexner, L. B., Harvey Lectures, Series 47, 156 (1952).
Richter, D., Brit. Med. Bull., 17, 118 (1961).
Levi-Montalcini, R., Prog. Brain Res., 4, 1 (1964).
Ballantyne, B., and Burwell, R., Nature, 206, 1123 (1965).
Dawson, D., Goodfriend, T., and Kaplan, N. O., Science, 143, 929 (1964).
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LAGNADO, J., HARDY, M. Brain Esterases during Development. Nature 214, 1207–1210 (1967). https://doi.org/10.1038/2141207a0
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DOI: https://doi.org/10.1038/2141207a0
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