Abstract
THE final stage of blood coagulation, the conversion of fibrinogen to fibrin by thrombin, is associated with the release of two acidic peptides designated A and B in the bovine system1. These peptides have been fully characterized by physico-chemical, chemical and enzyme methods, and the exact amino-acid sequence has been determined2. Laki3 has shown that the peptides released from fibrinogen affected the frog heart, and experiments carried out in this laboratory have indicated that 4 × 10−5 molar bovine peptide-B (Fig. 1) produces a slow contraction of the rabbit carotid artery strip, while in a concentration of 1.6 × 10−6 molar the peptide markedly potentiated the bradykinin-induced contraction of the isolated oestrus rat uterus. The present experiments were undertaken to ascertain whether bovine peptide-B has any vasopressor effect in vivo.
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References
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COLMAN, R., OSBAHR, A. & MORRIS, R. New Vasoconstrictor, Bovine Peptide-B, released during Blood Coagulation. Nature 214, 1040–1041 (1967). https://doi.org/10.1038/2141040a0
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DOI: https://doi.org/10.1038/2141040a0
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