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Inter Heavy–Light Chain Disulphide Bridge in Immune Globulins

Naturevolume 214pages9294 (1967) | Download Citation

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Abstract

THE immune globulins are a heterogeneous family of proteins made up of light and heavy* chains joined by disulphide bridges. Immunological techniques1,2 and chemical investigation3 indicate that most or all of the normal population of light chains is a mixture of two types of polypeptide—ϰ and λ. The majority of heavy chains can be classified as γ, μ or α. In humans, the γ chains have been further subdivided, making use of common antigenic determinants, into four major sub-classes: γ2a (or Ne), γ2b (or We), γ2c (or Vi), and γ2d (or Ge)4,5.

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Affiliations

  1. M.R.C. Laboratory of Molecular Biology, Hills Road, Cambridge

    • J. R. L. PINK
    •  & C. MILSTEIN

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https://doi.org/10.1038/214092a0

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