Abstract
THE immune globulins are a heterogeneous family of proteins made up of light and heavy* chains joined by disulphide bridges. Immunological techniques1,2 and chemical investigation3 indicate that most or all of the normal population of light chains is a mixture of two types of polypeptide—ϰ and λ. The majority of heavy chains can be classified as γ, μ or α. In humans, the γ chains have been further subdivided, making use of common antigenic determinants, into four major sub-classes: γ2a (or Ne), γ2b (or We), γ2c (or Vi), and γ2d (or Ge)4,5.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Mannik, M., and Kunkel, H. G., J. Exp. Med., 117, 213 (1963).
Fahey, J. L., J. Immunol., 91, 438 (1963).
Milstein, C., Nature, 205, 1171 (1965).
Grey, H. M., and Kunkel, H. G., J. Exp. Med., 120, 253 (1964).
Terry, W. D., and Fahey, J. L., Science, 146, 400 (1964).
Brown, J. R., and Hartley, B. S., Biochem. J., 101, 214 (1966).
Milstein, C., Biochem. J., 101, 338 (1966).
Cleland, W. W., Biochemistry, 3, 480 (1964).
Harris, J. I., Methods in Enzymology, 7 (edit. by Colowick, S. P., and Kaplan, N. O.) (Academic Press, New York, in the press).
Terry, W. D., Fahey, J. L., and Steinberg, A. G., J. Exp. Med., 122, 1087 (1965).
Fleischman, J. B., Porter, R. R., and Press, E. M., Biochem. J., 88, 220 (1963).
Frangione, B., Franklin, E. C., Fudenberg, H. H., and Koshland, M. E., J. Exp. Med., 124, 715 (1966).
Weir, R. C., Porter, R. R., and Givol, D., Nature, 212, 205 (1966).
Prahl, J. W. (personal communication).
Todd, C. W., Biochim. Biophys. Res. Commun., 11, 170 (1963).
Feinstein, A., Nature, 199, 1197 (1963).
Haber, E., Proc. U.S. Nat. Acad. Sci., 52, 1099 (1964).
Whitney, P. L., and Tanford, C., Proc. U.S. Nat. Acad. Sci., 53, 524 (1965).
Wilkinson, J. M., Press, E. M., and Porter, R. R., Biochem. J., 100, 303 (1966).
Litwin, S. D., and Kunkel, H. G., Fed. Proc., 25, No. 2, 1024, 371 (1965).
Hilschmann, N., and Craig, L. C., Proc. U.S. Nat. Acad. Sci., 53, 1403 (1965).
Titani, K., Whitley, E., Avogardo, L., and Putnam, F. W., Science, 149, 1090 (1965).
Milstein, C., Nature, 209, 370 (1966).
Bull. Wld. Hlth. Org., 30, 447 (1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
PINK, J., MILSTEIN, C. Inter Heavy–Light Chain Disulphide Bridge in Immune Globulins. Nature 214, 92–94 (1967). https://doi.org/10.1038/214092a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/214092a0
This article is cited by
-
Disulfide Scrambling in IgG2 Monoclonal Antibodies: Insights from Molecular Dynamics Simulations
Pharmaceutical Research (2011)
-
Immunoglobulins: Chemical Typing of Immunoglobulins
Nature (1969)
-
Immunoglobulins: Structural Studies of Immunoglobulin G
Nature (1969)
-
Disulphide Bridges of Immunoglobin G1 Heavy Chains
Nature (1967)
-
Disulphide Bridges of a Human Immunoglobulin G Protein
Nature (1967)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
