Abstract
SALMONELLIN is a new colicin-like antibiotic characterized by its wide range of activity on the salmonellae and its failure to affect strains of Escherichia coli. Other Salmonella colicins have a much more restricted activity1,2. It is produced by a strain of Salmonella eastbourne, SC 11, from my collection of local isolates. During an investigation of about 2,000 strains of Salmonella for colicin-like activity, the new antibiotic was found only in this one strain. Using Fredericq's double layer technique3 with the indicator organism, Salmonella gallinarum, which is useful in the detection of certain colicin-like reactions and bacteriophage, Salmonella SC 11 produced a very large, clear, ill-defined zone of inhibition. On nine strains of E. coli, including K 12 58/161 and phi (said to be sensitive to all colicins), SC 11 had no action.
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References
Hamon, Y., and Peron, Y., C.R. Acad. Sci., Paris, 258, 4162 (1964).
Hamon, Y., and Peron, Y., Ann. Inst. Pasteur, 106, 44 (1964).
Fredericq, P., Ergeb. der Microbiol. und Immunitatsforsch., 37, 114 (1963).
Kauffmann, F., Bakteriologie der Salmonella Species, (Munksgard, Copenhagen, 1961).
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ATKINSON, N. Salmonellin—a New Colicin-like Antibiotic. Nature 213, 184–185 (1967). https://doi.org/10.1038/213184a0
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DOI: https://doi.org/10.1038/213184a0
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