Letter | Published:

Effect of Thrombin, Adenosine Diphosphate, Connective Tissue, and Endotoxin on Platelet Glycolysis

Nature volume 212, page 508 (29 October 1966) | Download Citation

Subjects

Abstract

THROMBIN, which aggregates platelets, also induces an increase in rate of platelet glycolysis1,2. Other substances capable of aggregating platelets include adenosine diphosphate (ADP)3, connective tissue4, and (in rabbit platelet systems) endotoxin5. I have compared these other aggregating substances with thrombin in their ability to influence platelet glycolysis as measured by the production of lactate.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , and , Thromb. Diath. Haemorrh., 4, 178 (1960).

  2. 2.

    , J. App. Physiol. (in the press).

  3. 3.

    , , , , and , Nature, 192, 531 (1961).

  4. 4.

    , and , Proc. Soc. Exp. Biol. and Med., 109, 779 (1962).

  5. 5.

    , , and , J. Exp. Med., 116, 619 (1962).

  6. 6.

    , Standard Methods of Clinical Chemistry, 3, 167 (Academic Press, New York, 1961).

  7. 7.

    , and , Thromb. Diath. Haemorrh., 7, 480 (1982).

Download references

Author information

Affiliations

  1. Department of Medicine, George Washington University, D.C. General Hospital, Washington, D.C.

    • MILTON CORN

Authors

  1. Search for MILTON CORN in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/212508a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.