Abstract
THE inhibition of purine biosynthesis de novo in tumour cells by purines and purine analogues has been demonstrated by several workers1–3. The localization of the inhibition at the first reaction in this pathway, 5-phosphoribosyl-1-pyrophosphate-amidotransferase, was suggested by investigations with partially purified preparations of the enzyme from pigeon liver4–6 and bacteria7,8, and was supported by the results of investigations using intact tumour cells9. Preliminary work using crude rat liver extract agrees with these conclusions6.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Henderson, J. F., Prog. Exp. Tumour Res., 6, 85 (1965).
Bennett, jun., L. L., and Smithers, D., Biochem. Pharmacol., 13, 1331 (1964).
Brockman, R. W., and Chumley, S., Biochim. Biophys. Acta, 95, 365 (1965).
Wyngaarden, J. B., and Ashton, D. B., J. Biol. Chem., 234, 1492 (1959).
McColliester, R. J., Gilbert, jun., M. R., Ashton, D. M., and Wyngaarden, J. B., J. Biol. Chem., 239, 1560 (1964).
Caskey, C. T., Ashton, D. M., and Wyngaarden, J. B., J. Biol. Chem., 239, 2570 (1964).
Rottman, F., and Guarino, A. J., Biochim. Biophys. Acta, 89, 465 (1964).
Nierlich, D. P., and Magasanik, B., J. Biol. Chem., 240, 358 (1965).
Henderson, J. F., and Khoo, M. K. Y., J. Biol. Chem., 240, 3104 (1965).
Henderson, J. F., Biochem. Pharmacol., 12, 551 (1963).
Bennett, jun., L. L., Brockman, R. W., Schnebli, H. P., Chumley, S., Dixon, G. J., Schabel, jun., F. M., Dulmage, E. A., Skipper, H. E., Montgomery, J. A., and Thomas, H. J., Nature, 205, 1276 (1965).
Coldwell, I. C., Henderson, J. F., and Paterson, A. R. P., Canad. J. Biochem. (in the press).
LePage, G. A., Cancer Res., 13, 178 (1953).
Mercer, N. J. H., and Henderson, J. F., Anal. Biochem. (in the press).
Hogben, C. A. M., J. Lab. Clin. Med., 64, 815 (1964).
Conway, E. G., and Conway, C. F., J. Biol. Chem., 142, 839 (1942).
Zuckerman, R., Drell, W., and Levin, M. H., Arth. and Rheumat., 2, 46 (1959).
Grayzel, A. J., Seegmiller, J. E., and Love, E., J. Clin. Invest., 39, 447 (1960).
Krakoff, I. H., Balis, M. E., and Karnofsky, D. A., Ann. Intern. Med., 54, 1045 (1961).
Seegmiller, J. E., Laster, L., and Stetten, jun., D., J. Biol. Chem., 216, 653 (1955).
Seegmiller, J. E., Laster, L., and Stetten, jun., O., Ninth Intern. Cong. Rheumatic Diseases, 2, 207 (1957).
Seegmiller, J. E., Laster, L., and Howell, R. P., N. Eng. J. Med., 268, 712, 764, 821 (1963).
Wyngaarden, J. B., in The Metabolic Basis of Inherited Disease, edit. by Stanbury, J. B., Wyngaarden, J. B., and Frederickson, D. C., 679 (McGraw-Hill, New York, 1960).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HENDERSON, J., MERCER, N. Feedback Inhibition of Purine Biosynthesis de novo in Mouse Tissues in vivo. Nature 212, 507–508 (1966). https://doi.org/10.1038/212507a0
Issue Date:
DOI: https://doi.org/10.1038/212507a0
This article is cited by
-
Metabolic fingerprints of fear memory consolidation during sleep
Molecular Brain (2021)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.