Letter | Published:

Immunological Cross-reactivities of Cephalothin and its Related Compounds with Benzylpenicillin (Penicillin G)

Nature volume 212, pages 419420 (22 October 1966) | Download Citation



CEPHALOTHIN, a newly developed semi-synthetic antibiotic, has a β-lactam dihydrothiazine ring system as a molecular nucleus. The similarity of its structural formula to that of penicillin G (PC-G) suggests that cephalothin (CET) may obtain antigenicity through irreversible covalent bonding to proteins, as occurs with PC-G.

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  1. Department of Internal Medicine, University of Hokkaido, Sapporo, Japan.

    • K. SHIBATA
    • , T. ATSUMI
    • , Y. HORIUCHI
    •  & K. MASHIMO


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