Letter | Published:

Hypo or Hyper Coagulability of Blood with High Levels of Clotting Factors?

Nature volume 212, page 417 (22 October 1966) | Download Citation



ORAL contraceptive drugs have recently been reported to produce an increase in blood factors VII and VIII1 and fibrinogen2. Vascular thrombosis has been suspected during the administration of these drugs, and this raises for consideration the effect of high levels of clotting factors on the coagulability of blood. Experiments were carried out before and after the blood was in contact with wettable surfaces.

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  1. 1.

    , and , Brit. Med. J., i, 220 (1963).

  2. 2.

    , and , Lancet, ii, 10 (1964).

  3. 3.

    , Ann. N.Y. Acad. Sci., 105, 983 (1964).

  4. 4.

    Chicago Conf. on Thromboembolic Phenomena in Women. Searle (1962); , and , New Engl. J. Med., 269, 622 (1963); , , and , Brit. Med. J., i, 1586 (1965).

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  1. Department of Pathology, Shenley Hospital, nr. St. Albans, Hertfordshire.

  2. Department of Pathology, Southmead Hospital, Bristol.

    • F. J. W. LEWIS


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