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Influence of Catecholamines on Nucleotide-induced Platelet Aggregation

Naturevolume 212pages415417 (1966) | Download Citation



BECAUSE platelet aggregation is probably important in the pathogenesis of thrombosis, interest in this phenomenon is increasing. Hellem1 noted that an acidic, dialysable and heat-stable extract of red cells was able to produce marked platelet aggregation in citrated or oxalated plasma. This red-cell factor was afterwards identified as adenosine diphosphate (ADP) by Gaarder et al.2, who found it to be the most potent of twenty-two nucleotides tested. Other compounds have since been shown to induce platelet aggregation, and these include adenosine triphosphate (ATP)3,4, and certain catecholamines, namely adrenaline5,6 and noradrenaline4,7. In this communication the effects of the three catecholamines, adrenaline, noradrenaline and dopamine, on platelet aggregation induced in vitro by nucleotides are described and discussed.

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  1. Institute of Medical and Veterinary Science, Adelaide, South Australia

    • N. G. ARDLIE
    • , G. GLEW
    •  & C. J. SCHWARTZ


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