Letter | Published:

Insulin Resistance of the Inherently Obese Mouse—obob

Naturevolume 212pages289290 (1966) | Download Citation



MAYER and his colleagues first demonstrated the insulin resistance of the mutant obese1 soon after its discovery in 1949. Further work amplified the nature of the resistance: the level of blood glucose was significantly higher, after administration of insulin, than that of normal animals, and it was not possible to put the mutants into an insulin coma or convulsions, even after giving massive doses far in excess of lethal quantities2–4.


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    Mayer, J., Bates, M. W., and Dickie, M. M., Science, 113, 746 (1951).

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    Mayer, J., Andrus, S. B., and Silides, D. J., Endocrinology, 53, 572 (1953).

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    Shull, K. H., and Mayer, J., Endocrinology, 58, 1 (1956).

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    Shull, K. H., and Mayer, J., Endocrinology, 58, 220 (1956).

  5. 5

    Mayer, J., Physiol. Rev., 33, 472 (1953).

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    Kennedy, G. C., and Parker, R. A., Lancet, ii, 981 (1963).

  7. 7

    Girolamo, M. D., Rudman, D., Malkin, M. F., and Garcia, L. A., Diabetes, 14, 87 (1965).

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    • R. BATT

    Present address: M.R.C. Unit, Department of Biochemistry, Imperial College, London


  1. Institut de Physiologic et Chemie Biologique, Rue Descartes, Strasbourg, France

    • R. BATT
    •  & P. MIALHE


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