Abstract
THE capacity of passively administered serum antibody to inhibit specific antibody formation1 has suggested that serum antibody may act as a type of “feedback” mechanism2–5. It is not known whether this effect of antibody results from its interaction with antigen or from a “direct” effect of some kind on the antibody-producing cells themselves5. A “direct” effect might be mediated by the Fc fragment of antibody, because this fragment, which does not contain the combining sites for antigen, is known to be essential for many other biological functions of antibody, such as complement fixation6, combination with skin7 and passage across the placenta8. The purpose of our experiments was to determine whether this fragment of the antibody gamma-globulin plays a part in the inhibition by antibody of specific antibody formation.
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TAO, TW., UHR, J. Capacity of Pepsin-digested Antibody to inhibit Antibody Formation. Nature 212, 208–209 (1966). https://doi.org/10.1038/212208a0
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DOI: https://doi.org/10.1038/212208a0
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