Letter | Published:

Effect of Yeast Pyruvate Decarboxylase on Ehrlich Ascites Carcinoma in vivo

Naturevolume 212page201 (1966) | Download Citation



THIS communication reports on the inhibition of the reduction of pyruvate to lactate, catalysed by lactate dehydrogenase with NADH as coenzyme. This is of interest in an attempt to block glycolysis in tumour cells1,2.

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    Busch, H., and Nair, P. V., J. Biol. Chem., 229, 377 (1957).

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    Busch, H., Amer, S. M., and Davis, J. R., J. Amer. Pharm. Assoc., 49, 16 (1960).

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    Neuberg, C., and Karczag, L., Biochem. Z., 37, 170 (1911).

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    Rommel, A. J. (in preparation).

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    Holzer, H., Schultz, G., Villar-Palasi, C., and Jüntgen-sell, Biochem. Z., 327, 331 (1956).

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    Holzer, H., and Goedde, H. W., Biochem. Z., 329, 192 (1957).

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  1. Physiologisches Institut, Universität Tübingen

    • A. J. ROMMEL


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