Abstract
N-(γ-DL-Glutamyl) amino acetonitrile (GAAN), a synthetic analogue of β-(N-γ-DL-glutamyl) amino propionitrile (GBAPN), the lathyrus factor in the sweet pea (Lathyrus odoratus), has previously been shown to be a lathyrogen in vivo1. Recently a quite different action has been observed in vitro in that the agent specifically prevents the formation of cartilage matrix in chick limb bone rudiments in organ culture.
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References
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McCALLUM, H., ARBUTHNOTT, J. Effect of Certain Nitriles on Cartilage Synthesis in vitro. Nature 212, 1489–1490 (1966). https://doi.org/10.1038/2121489a0
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DOI: https://doi.org/10.1038/2121489a0
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