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Ontogeny of Cattle Haemoglobin

Nature volume 212, pages 1272–1273 (1966)Cite this article

Abstract

THREE different types of haemoglobin appear at various stages of development of the human embryo and foetus. The existence of an embryonic haemoglobin1 was long in question until Huehns2 and Kleihauer3 confirmed that it occurs in normal human embryos of crown-rump length less than 8.5 cm. The quantitative relations and chemical properties of the embryonic haemoglobins Gower 1 and Gower 2 were thoroughly studied by Huehns et al.2. As the foetus develops, adult haemoglobin is produced in increasing amounts, and 6 months after birth it has almost completely replaced the foetal haemoglobin. The relation between the increased adult haemoglobin production and the increasing bone marrow activity during foetal stages is purely chronological. Foetal and adult haemoglobin can be synthesized in the liver as well as in bone marrow4,5.

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Authors and Affiliations

  1. Universitätskinderklinik, Tübingen, Germany

    E. KLEIHAUER, E. BRAUCHLE & G. BRANDT

Authors
  1. E. KLEIHAUER
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  2. E. BRAUCHLE
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  3. G. BRANDT
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KLEIHAUER, E., BRAUCHLE, E. & BRANDT, G. Ontogeny of Cattle Haemoglobin. Nature 212, 1272–1273 (1966). https://doi.org/10.1038/2121272a0

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