Abstract
THE lethal effect of ultra-violet light on living cells is believed to result from the formation of pyrimidine dimers in DNA molecules1. The different sensitivities of mutants of certain bacteria to ultra-violet light have been investigated in the light of the knowledge that ultraviolet-sensitive mutants have defective mechanisms for the repair of damaged DNA by enzymes while in ultraviolet-resistant strains this mechanism is unimpaired2,3. The mechanism of repair proposed by Boyce and Howard-Flanders2 and Setlow and Carrier3 involves the removal thymine dimers from the DNA in Escherichia coli strains K12 and B/r, respectively, irradiated with ultra-violet light.
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References
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SUZUKI, K., MORIGUCHI, E. & HORII, ZI. Stability of DNA in Escherichla coli B/r and BS–1 irradiated with Ultra-violet Light. Nature 212, 1265–1267 (1966). https://doi.org/10.1038/2121265a0
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DOI: https://doi.org/10.1038/2121265a0
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