Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Post-irradiation Changes in the Deoxyribonucleoprotein Complex in Animal Tissues as revealed by the Action of Heparin

Nature volume 212, pages 1253–1255 (1966)Cite this article

Abstract

IT has been shown1–6 that “labilization” of the bond between DNA and protein occurs in certain tissues after irradiation, which manifests itself in the release of deoxyribopolynucleotides, easier deproteinization, and an increase in the solubility of the deoxyribonucleoprotein (DNP) complex in solutions of a high ionic strength. Little is known, however, of either the mechanism or the nature of these changes, or of their biological significance. In order to ascertain whether there is any change in the strength of the bond between DNA and protein after irradiation, we have investigated the interaction of heparin with the DNP complex of various tissues of normal and irradiated animals.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Cole, L. J., and Ellis, M. E., Radiat. Res., 7, 508 (1957).

    Article  ADS  CAS  Google Scholar 

  2. Hagen, U., Nature, 187, 1123 (1960).

    Article  ADS  CAS  Google Scholar 

  3. Bauer, R. D., Dreher, K., and Kurnick, N. B., Radiat. Res., 20, 24 (1963).

    Article  ADS  CAS  Google Scholar 

  4. Skalka, M., Matyášová, J., and Soška, J., Proc. Symp. Biological Effects of Ionizing Radiation at the Molecular Level, 323 (IAEA, Vienna, 1962).

    Google Scholar 

  5. Skalka, M., and Matyášová, J., Intern. J. Rad. Biol., 7, 41 (1963).

    CAS  Google Scholar 

  6. Skalka, M., Matyášová, J., and Chlumecká, V., Folia Biol., 11, 113 and 378 (1965).

    CAS  Google Scholar 

  7. Kent, P. W., Hichens, M., and Ward, P. F. V., Biochem. J., 68, 568 (1958).

    Article  CAS  Google Scholar 

  8. Mirsky, A. E., and Ris, H., J. Gen. Physiol., 34, 475 (1951).

    Article  CAS  Google Scholar 

  9. Phillips, D. M. P., Prog. Biophys., 12, 211 (1962).

    CAS  Google Scholar 

  10. Frenster, J. H., Nature, 206, 680 (1965).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Biophysics, Czechoslovak Academy of Sciences, Brno, Czechoslovakia

    M. SKALKA & J. MATYÁŠOVÁ

Authors
  1. M. SKALKA
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. MATYÁŠOVÁ
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

SKALKA, M., MATYÁŠOVÁ, J. Post-irradiation Changes in the Deoxyribonucleoprotein Complex in Animal Tissues as revealed by the Action of Heparin. Nature 212, 1253–1255 (1966). https://doi.org/10.1038/2121253a0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/2121253a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing