Abstract
THE development of improved methods for the isolation and determination of hydroxyproline from bone1 has made it possible to study collagen turnover in vivo in calcified tissues with a higher degree of accuracy than was previously attainable. This is accomplished by the administration of carbon-14-proline, followed by the isolation of hydroxyproline. The conversion of proline to hydroxyproline is a measure of collagen formation2.
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References
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FIRSCHEIN, H., MILLER, O. Comparison of Calcium-48 and Carbon-14-proline as Indicators of Bone Metabolism. Nature 212, 1252–1253 (1966). https://doi.org/10.1038/2121252b0
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DOI: https://doi.org/10.1038/2121252b0
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