Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Some Pharmacological Properties of a New Adrenergic β-Receptor Antagonist

Nature volume 212, pages 88–90 (1966)Cite this article

Abstract

SEVERAL compounds have now been described as adrenergic β-receptor antagonists including dichloroisoprenaline1 pronethalol (‘Alderlin’)2, propranolol (‘Inderal’)3, MJ 1999 (ref. 4), and INPEA5. Propranolol is about ten times more active than the other compounds in blocking the inotropic and chronotropic actions of catecholamines6. Studies with pronethalol and propranolol have shown that adrenergic β-receptor antagonists are valuable in the treatment of various clinical disorders7–11. The use of pronethalol was restricted when it was shown to be a potential carcinogenic agent in mice12; propranolol is devoid of this action13. This communication describes some of the pharmacological properties of a new adrenergic β-receptor antagonist 1-isopropylamino-3-(3-tolyloxy)-2-propanol hydrochloride (‘I.C.I. 45,763’), selected from a series of phenoxypropanolamines synthesized by Crowther Smith and Wood14.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Powell, C. E., and Slater, I. H., J. Pharmacol., 122, 480 (1958).

    CAS  Google Scholar 

  2. Black, J. W., and Stephenson, J. S., Lancet, ii, 311 (1962).

  3. Black, J. W., Crowther, A. F., Shanks, R. G., Smith, L. H., and Dornhorst, A. C., Lancet, i, 1080 (1964).

  4. Lish, P. M., Weikel, J. H., and Dungan, K. W., J. Pharmacol., 149, 161 (1965).

    CAS  Google Scholar 

  5. Teotino, U. M., Polo Friz, L., Streis, G., and Della Bella, D., J. Pharm. Pharmacol., 15, 26 (1963).

    Article  CAS  Google Scholar 

  6. Shanks, R. G., Biochem. Pharmacol. (in the press).

  7. Stock, J. P. P., and Dale, N., Brit. Med. J., ii, 1230 (1963).

  8. Rowlands, D. J., Howitt, G., and Markman, P., Brit. Med. J., i, 891 (1965).

  9. Hamer, J., Grandjean, T., Melendez, L., and Sowton, G. E., Brit. Med. J., ii, 720 (1964).

  10. Gillam, P. M. S., and Prichard, B. N. C., Brit. Med. J., ii, 337 (1965).

  11. Goodwin, J. F., Shah, P. M., Oakley, C. M., Cohen, J., Yipintsoi, T., and Pocock, W., Ciba Found. Symp., Cardiomyopathies, 189 (1964).

  12. Alcock, S. J., and Bond, P. A., Proc. Europ. Soc. Study Drug Toxic., 4, 30 (1965).

    Google Scholar 

  13. Tucker, M. J., Alcock, S. J., and Baker, S. B. de C., Brit. Med. J., ii, 363 (1965).

  14. Crowther, A. F., Smith, L. H., and Wood, T. M., U.K. Patent Application No. 46740/62, Belgian Patent No. 641,133.

  15. Black, J. W., Duncan, W. A. M., and Shanks, R. G., Brit. J. Pharmacol., 25, 577 (1965).

    CAS  PubMed  Google Scholar 

  16. Orlans, F. B. H., Finger, K. F., and Brodie, B. B., J. Pharmacol., 128, 131 (1960).

    CAS  Google Scholar 

  17. Levy, B., and Ahlquist, R. P., J. Pharmacol., 133, 202 (1961).

    CAS  Google Scholar 

  18. Stock, K., and Westerman, E., Biochem. Pharmacol., 14, 227 (1965).

    Article  CAS  Google Scholar 

  19. Baker, S. B. de C. (personal communication).

Download references

Author information

Authors and Affiliations

  1. Pharmaceuticals Division, Imperial Chemical Industries, Ltd., Alderley Park, Macclesfield, Cheshire

    R. G. SHANKS & T. M. WOOD

  2. Medical Unit, St. George's Hospital, London, S.W.1.

    A. C. DORNHORST & M. L. CLARK

Authors
  1. R. G. SHANKS
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. M. WOOD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. C. DORNHORST
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. L. CLARK
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

SHANKS, R., WOOD, T., DORNHORST, A. et al. Some Pharmacological Properties of a New Adrenergic β-Receptor Antagonist. Nature 212, 88–90 (1966). https://doi.org/10.1038/212088a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/212088a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing