Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Heterogeneity of Rabbit Serum Interferons

Nature volume 211, pages 541–542 (1966)Cite this article

Abstract

THERE is evidence that, in the rabbit, virus-induced interferon (VII) is induced differently from endotoxin-induced interferon (EII). The induction of VII is inhibited by actinomycin D (ref. 1) and by puromycin2, while the induction of EII is not. Furthermore, Hallum et al.3 demonstrated that, in the mouse, the molecular weight of EII is greater than that of VII. In view of these differences between EII and VII, we decided to study the molecular sizes of rabbit serum interferons induced by virus and by endotoxin.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Ho, M., and Kono, Y., Proc. U.S. Nat. Acad. Sci., 53, 220 (1965).

    Article  ADS  CAS  Google Scholar 

  2. Ke, Y. H., et al., Proc. Soc. Exp. Biol. and Med., 121, 181 (1966).

    Article  CAS  Google Scholar 

  3. Hallum, J. V., Youngner, J. S., and Stinebring, W. R., Virology, 27, 429 (1965).

    Article  CAS  Google Scholar 

  4. Postic, B., et al., J. Bacteriol., 91, 1277 (1966).

    CAS  Google Scholar 

  5. Ho, M., Science, 146, 1472 (1964).

    Article  ADS  CAS  Google Scholar 

  6. Merigan, T. C., et al., J. Mol. Biol., 13, 679 (1965).

    Article  CAS  Google Scholar 

  7. Andrews, P., Biochem. J., 96, 595 (1965).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Epidemiology and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania

    YANG H. KE & MONTO HO

  2. Department of Medicine, Stanford University School of Medicine, Palo Alto, California

    THOMAS C. MERIGAN

Authors
  1. YANG H. KE
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. MONTO HO
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. THOMAS C. MERIGAN
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

KE, Y., HO, M. & MERIGAN, T. Heterogeneity of Rabbit Serum Interferons. Nature 211, 541–542 (1966). https://doi.org/10.1038/211541a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/211541a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing