Abstract
AMONG the genetic variants of adult human haemoglobin, some thirteen amino-acid substitutions have been described which occur along the primary sequence of the α-polypeptide chain. The most widespread and frequently encountered α-chain variant is the substitution of lysine for asparagine in the 68th residue of haemoglobin A (ref. 1). A structural mutation leading to the substitution of asparagine by lysine in a protein can be the direct result of a single nucleotide base alteration within the triplet code. Here an alteration in triplet AAU or AAC specifying asparagine could result in AAA or AAG which code for lysine2. Haemoglobin variants carrying a substitution of lysine for asparagine in the 68th residue of the polypeptide chain have been described in Negro families living in Philadelphia1, Bristol3, Azuokoli, St. Louis, Washington and Baltimore4, and Knoxville6.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Baglioni, C., and Ingram, V. M., Biochim. Biophys. Acta, 48, 253 (1961).
Nirenberg, M., Leder, P., Bernfield, M., Brimacombe, R., Trupin, J., Rottman, F., and O'Neal, C., Proc. U.S. Nat. Acad. Sci., 53, 1161 (1965).
Dance, N., Huehns, E. R., and Shooter, E. M., Biochim. Biophys. Acta, 86, 144 (1964).
Weatherall, D. J., Sigler, A. T., and Baglioni, C., Bull. Johns Hopkins Hosp., 111, 143 (1962).
Chernoff, A. I., and Pettit, N., Biochim. Biophys. Acta, 97, 47 (1965).
Schneider, R. G., and Haggard, M. E., Brit. Med. J., ii, 285 (1959).
Dherte, P., Vandepitte, J., Ager, J. A. M., and Lehmann, H., Brit. Med. J., ii, 282 (1959).
Bowman, B. H., Oliver, C. P., Barnett, D. R., Cunningham, J. E., and Schneider, R. G., Blood, 23, 193 (1964).
Braunitzer, G., Rudloff, V., Hilse, K., Liebold, B., and Müller, R., Z. Physiol. Chem., 320, 283 (1960).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BOWMAN, B., BARNETT, D., HODGKINSON, K. et al. Chemical Characterization of Haemoglobin GSt-I. Nature 211, 1305–1306 (1966). https://doi.org/10.1038/2111305a0
Issue Date:
DOI: https://doi.org/10.1038/2111305a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
