Abstract
RECENTLY, the aggregation of sRNA from Escherichia coli has been reported1. At neutral pH and at 25° C the aggregation process is dependent on nucleic acid and magnesium ion concentration. In 0.02 M magnesium, the aggregates dissociate into monomer units at low nucleic acid concentrations. This report shows that a modest increase in temperature (from 25° C to 45° C) partially dissociates the aggregates and that the decrease in molecular weight is reflected in the viscosity thermal profile.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Millar, D. B., and Steiner, R. F., Biochemistry, 5, 2289 (1966).
Fraenkel-Conrat, H., Singer, B., and Tsugita, A., Virology, 14, 54 (1961).
Stephenson, M. L., and Zamecnik, P. C., Proc. U.S. Nat. Acad. Sci., 47, 1627 (1961).
Lipsett, M. N., Heppel, L. A., and Bradley, D. F., J. Biol. Chem., 236, 857 (1961).
Henley, D. D., Lindahl, T., and Fresco, J. R., Proc. U.S. Nat. Acad. Sci., 55, 191 (1966).
Millar, D. B., and MacKenzie, M., Biochem. Biophys. Res. Commun., 5, 724 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MILLAR, D. Effect of Temperature on s-Ribonucleic Acid Aggregation induced by Magnesium Ions. Nature 211, 1088–1089 (1966). https://doi.org/10.1038/2111088b0
Issue Date:
DOI: https://doi.org/10.1038/2111088b0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.