Abstract
THE unique action of aniline mustard (I) and closely related analogues in curing mice bearing advanced plasma cell tumours (up to 8 g in weight) was recently described1. From an investigation of a series of derivatives related to aniline mustard it was postulated that this compound was hydroxylated in the liver to form the highly toxic p-hydroxyaniline mustard (II), and then detoxified by conversion to the glucuronide or sulphate. A high glucuronidase or sulphatase activity of the tumour would result in the selective release in the tumour of the toxic p-hydroxy derivative:
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References
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CONNORS, T., WHISSON, M. Cure of Mice bearing Advanced Plasma Cell Tumours with Aniline Mustard : the Relationship between Glucuronidase Activity and Tumour Sensitivity. Nature 210, 866–867 (1966). https://doi.org/10.1038/210866b0
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DOI: https://doi.org/10.1038/210866b0
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