Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Vitamin B12 Concentrations in Human Tissues

Nature volume 210, pages 1264–1265 (1966)Cite this article

Abstract

THE development of microbiological technique for evaluating vitamin B12 concentration has made it possible to measure the wide variations in the quantity of vitamin B12 present in sera from humans in normal and various pathological states. By this means, the concentration of serum B12 has been found to be above normal in hepatitis1, cirrhosis2 and myelogenous leukaemia3, but below normal in pernicious anaemia4, total gastrectomy5, sprue6, old age7 and pregnancy8.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Jones, P. N., and Mills, E. H., J. Lab. Clin. Med., 46, 927 (1955).

    Google Scholar 

  2. Stevenson, T. D., and Beard, M. F., Clin. Res. Proc., 4, 144 (1956).

    Google Scholar 

  3. Beard, M. F., Pitney, W. R., and Sanneman, E. H., Blood, 9, 789 (1954).

    CAS  PubMed  Google Scholar 

  4. Lear, A. A., Harris, J. W., Castle, W. B., and Fleming, E. M., J. Lab. Clin. Med., 44, 715 (1954).

    CAS  PubMed  Google Scholar 

  5. Paulson, M., and Harvey, J. C., J. Amer. Med. Assoc., 156, 1556 (1954).

    Article  CAS  Google Scholar 

  6. Reisner, jun., E. H., Rosenblum, C., and Morgan, M. D., Clin. Res. Proc., 11, 56 (1954).

    Google Scholar 

  7. Chow, B. F., Wood, R., Horonick, A., and Okuda, K., J. Gerontol., 11, 142 (1956).

    Article  CAS  Google Scholar 

  8. Boger, W. P., Wright, L. D., Beck, G. D., and Bayne, G. M., Proc. Soc. Exp. Biol. and Med., 92, 140 (1956).

    Article  CAS  Google Scholar 

  9. Hsu, J. M., Yeh, S. D. J., Buddemeyer, E. U., Hormazabal, J., and Chow, B. F., in Vitamin B12 and Intrinsic Factor, Second Europ. Symp. Vitamin B12 and Intrinsic Factor in Hamburg (August 1961), 2, 574 (Ferdinand Enkc, Stuttgart, 1962).

    Google Scholar 

  10. Girdwood, R. H., Biochem. J., 52, 58 (1952).

    Article  CAS  Google Scholar 

  11. Swendseid, M. E., Hvolboll, E., Schick, G., and Halsted, J. A., Blood, 12, 24 (1957).

    PubMed  Google Scholar 

  12. Pitney, W. R., Beard, M. F., and Van Loon, E. J., J. Biol. Chem., 212, 117 (1955).

    CAS  PubMed  Google Scholar 

  13. Woolley, D. W., Proc. U.S. Nat. Acad. Sci., 39, 6 (1953).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biochemistry Research Laboratory, Veterans Administration Hospital, Baltimore, Maryland

    JENG M. HSU

  2. Radioisotope Research Laboratory, Veterans Administration Hospital, Washington, D.C.

    BERGENE KAWIN

  3. Clinical Laboratory, St. Joseph's Hospital, Elmira, New York

    PHYLLIS MINOR & JAMES A. MITCHELL

Authors
  1. JENG M. HSU
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. BERGENE KAWIN
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. PHYLLIS MINOR
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. JAMES A. MITCHELL
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

HSU, J., KAWIN, B., MINOR, P. et al. Vitamin B12 Concentrations in Human Tissues. Nature 210, 1264–1265 (1966). https://doi.org/10.1038/2101264a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/2101264a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing