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Amino-acid Substitutions in Haemoglobins and the Mutation Process

Nature volume 210, pages 116–117 (1966)Cite this article

Abstract

VARIOUS genetically determined human and animal haemoglobins differ in the amino-acid sequences of their polypeptide chains1,3,6. On the basis of the ribonucleic acid triplets published recently4,5 all abnormal human haemoglobins which are due to single amino-acid substitutions can be explained by single base pair changes in the deoxyribonucleic acid. Comparing the normal human β- and δ-chains we found that only the exchange of threonine to glutamine in position 87 (1 of 10) cannot be interpreted by a single point mutation.

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Authors and Affiliations

  1. Institut für Anthropologie und Humangenetik der Universität, Heidelberg

    F. VOGEL & G. RÖHRBORN

Authors
  1. F. VOGEL
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  2. G. RÖHRBORN
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VOGEL, F., RÖHRBORN, G. Amino-acid Substitutions in Haemoglobins and the Mutation Process. Nature 210, 116–117 (1966). https://doi.org/10.1038/210116a0

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