Abstract
THE synthesis of collagen has been examined in cultures of various cell strains and established cell lines of fibroblastic origin1–5. All the strains and most of the established lines synthesized considerable quantities of collagen, but the rate of synthesis varied among the different strains and lines4,6. One line, 3T3, in contrast to others evolved from the same initial mouse embryo culture, was found to be severely restricted in its ability to synthesize collagen2,7, while transformants of this line produced by polyoma virus or SV40 were able to synthesize collagen at higher rates7. It therefore appeared that collagen synthesis in cell line 3T3 was repressed and this repression was released by the viral transformation.
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GREEN, H., TODARO, G. & GOLDBERG, B. Collagen Synthesis in Fibroblasts transformed by Oncogenic Viruses. Nature 209, 916–917 (1966). https://doi.org/10.1038/209916a0
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DOI: https://doi.org/10.1038/209916a0
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